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Chemo-optogenetic Dimerization Dissects Complex Biological Processes (Small Methods 7/2025)
Donglian Wu, Xiaofeng Sun, Xi Chen

In recent years, chemo-optogenetic dimerization tools, represented by photo-responsive chemical inducers of dimerization (pCIDs), have been developed for spatiotemporal regulation of cellular functions. These dimerizers enable turning ON (paCID), turning OFF (pdCID), or switching between ON/OFF (psCID) of cellular activities. Apart from Small molecule pCIDs, nanobody-conjugate photodimerizers are also emerging. These advancements create new opportunities for dissecting complex biological processes. More in article number 2401271, Chen and co-workers.